Using paroxetine — a medication prescribed to treat conditions including depression, obsessive-compulsive disorder, anxiety and posttraumatic stress disorder — during the first trimester of pregnancy may increase newborns’ risk of congenital malformations and cardiac malformations. Up to one-fifth of women of childbearing age experience depressive symptoms that often lead to mild to moderate depression, and prescriptions for antidepressants during pregnancy have increased in recent years. The most common drugs for treating depression in pregnant women are selective serotonin reuptake inhibitors, and up until 2005, one drug in that class — paroxetine — was considered to be safe for use during pregnancy.
Recurrence of HER2-positive breast cancer after treatment may be due to a specific and possibly cancer-induced weakness in the patient’s immune system — a weakness that in principle could be corrected with a HER2-targeted vaccine — according to a new study.
The world’s largest database for cancer drug discovery has been revolutionized by adding 3-D structures of faulty proteins and maps of cancer’s communication networks, according to a new report.
A new approach has been developed that allows researchers to broadly survey learning-related changes in synapse properties. The researchers used machine-learning algorithms to analyze thousands of images from the cerebral cortex. This allowed them to identify synapses from an entire cortical region, revealing unanticipated information about how synaptic properties change during development and learning.
A novel imaging-based method for defining appropriateness of breast cancer treatment is as accurate as the current standard-of-care and could reduce the need for invasive tissue sampling, new research shows. The results suggest that the method might lead to more optimal treatment of individual patients.
The presence of myopia, or nearsightedness, significantly affects the muscles used in focusing the lens of the eye — a finding with important implications for the development of ‘accommodating’ implanted intraocular lenses (IOLs) that can adjust to different visual distances, reports a new study.
Survivors of cancer pay thousands of dollars in excess medical expenditures every year, with the excess financial burden varying by age and cancer site, a new report suggests.
A web-based application has been developed to advance pediatric cancer research, collaboration and clinical care through enhanced exploration of the pediatric cancer genome, report researchers.
About 18,000 people are severely injured every year in Germany. Earlier investigations, in 2000 and 2006, estimated that more than 32,000 people sustain multiple trauma each year. The newly calculated lower number likely reflects a reduction of severe injuries caused by road traffic and occupational accidents.
The prevalence of chronic kidney disease varies across European countries, ranging from 3 percent to 17 percent. Differences in rates of diabetes, hypertension, and obesity — which are risk factors for chronic kidney disease — do not account for this variation.