Tag Archives: Caring for Elderly Relatives

Plasma levels of glucagon like peptide-1 associate with diastolic function in elderly men.

Diabet Med. 2011 Mar; 28(3): 301-305
Nathanson D, Zethelius B, Berne C, Lind L, Andrén B, Ingelsson E, Holst JJ, Nyström T

Diabet. Med. 28, 301-305 (2011) ABSTRACT: Aims? Congestive heart failure is a major cause of morbidity and mortality in diabetes. Besides the glycaemic effects of glucagon-like peptide?1 (GLP-1) mimetics, their effects on the heart are of interest. Methods? We aimed to investigate longitudinal relationships between plasma levels of fasting GLP-1 (fGLP-1), 60-min oral glucose tolerance test-stimulated GLP-1 levels (60GLP-1), and the dynamic GLP-1 response after oral glucose tolerance test (?GLP-1?=?60GLP-1?-?fGLP-1) and incidence of hospitalized congestive heart failure, during a follow-up time of a maximum of 9.8?years in 71-year-old men. We also investigated, cross-sectionally, the association between GLP-1 and left ventricular function as estimated by echocardiography. Results? During the follow-up period, 16 of 290 participants with normal glucose tolerance experienced a congestive heart failure event (rate 0.7/100?person-years at risk), as did eight of 136 participants (rate 0.8/100?person-years at risk) with impaired glucose tolerance and nine of 72 participants (rate 1.7/100?person-years at risk) with Type?2 diabetes mellitus. Although GLP-1 concentrations did not predict congestive heart failure (fGLP-1: HR?0.98, 95%?CI?0.4-2.4; 60GLP-1: HR?1.1, 95%?CI?0.4-2.6; ?GLP-1: HR?0.9, 95%?CI?0.3-2.3), there was an association between left ventricular diastolic function (E/A ratio) and fGLP-1 (r?=?0.19, P?=?0.001), 60GLP-1 (r?=?0.20, P?<?0.001) and ?GLP-1 (r?=?0.18, P?=?0.004). There was a lack of differences in plasma levels of GLP-1 between the groups with Type?2 diabetes and normal glucose tolerance. Conclusions? There were no longitudinal associations between GLP-1 levels and incidence of hospitalization for congestive heart failure. However, without any causality proven, GLP-1 levels did correlate, cross-sectionally, with left ventricular diastolic function in this cohort, suggesting that pathways including GLP-1 might be involved in the regulation of cardiac diastolic function.